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yvaE [2019-07-10 12:05:25]
similar to multidrug-efflux transporter
product
subunit of unidentified multidrug transporter
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.2|Transporters] → [category|SW 1.2.4|Transporters/ other] → [category|SW 1.2.4.14|Multidrug exporters][category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.14|Resistance against toxins/ antibiotics/ based on similarity][category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]Gene
Coordinates
3,448,693 3,449,052
The protein
Protein family
paired small multidrug resistance protein family ([SW|PSMR family]) [Pubmed|17942072][SW|drug/metabolite transporter (DMT) superfamily] (according to UniProt)[SW|Small multidrug resistance (SMR) (TC 2.A.7.1) family] (according to UniProt)Structure
[PDB|3B5D] (from E. coli, 44% identity) [pubmed|18024586][SW|Localization]
cell membrane (according to UniProt)Expression and Regulation
Operons
genes
[gene|97CE9735931D02E6E780C955C9BE3A67E5C4C59A|yvaF]-[gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]-[gene|B7FBC30B744D8B1F26AFC5DCB297FAFAB5C60FB7|yvaD]
description
[pubmed|22383849]
view in new tabBiological materials
Mutant
MGNA-A502 (yvaE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/502 NBRP B. subtilis, Japan]BKE33570 ([gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE33570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCCAAGCATAGAAACACCC, downstream forward: _UP4_GTACATAAAAGCGGGCAGTABKK33570 ([gene|230D790937DAFB82A04B8597699115E1C1EAE98E|yvaE]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK33570 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CGCCAAGCATAGAAACACCC, downstream forward: _UP4_GTACATAAAAGCGGGCAGTAReferences
Reviews
Original publications